CD16+_Monocyte

Ontology Term

CD14-low, CD16-positive monocyteCL:0002396

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

non-classical monocyte, human

Category

Class of which the cell type is a subclass.

monocyteCL:0000576

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

CD68, FCGR3A, CX3CR1, CDKN1C, CSF1R, ITGAL

Canonical Marker Genes

unknown

Rationale

Myeloid and pDC cells were identified via RCAv2. Integration and sub-clustering of all myeloid and pDC cells were performed, and these clusters were manually annotated based on expression of FCGR3A (CD16) and other marker genes. This annotation includes clusters that may contain intermediate monocytes.

Inherited from author_cell_type

Set of Labels Description

These author cell type labels were assigned largely at the per-cluster level. We identified broad cell types using RCAv2-based clustering (B, CD34+ haematopoietic stem and progenitor cell (HSPC), myeloid, natural killer (NK), plasma cell, plasmacytoid dendritic cell (pDC), platelet, and T). We then performed cell population-specific (B; myeloid + pDC; CD4+ T and dnT; non-CD4+ T and NK and ILC) integration (Seurat RPCA) and sub-clustering (Louvain clustering), and annotated clusters based on their marker genes.

Annotation Method

manual