B/DZ
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- lymph node centroblast, germinal center dark zone B cell
- CategoryClass of which the cell type is a subclass.
- germinal center B cellCL:0000844
- Rationale
- CD79B shows these are B cells
POU2AF1 and AICDA are germinal center markers for B cells, and AICDA points towards dark zone.
proliferation markers MKI67 and stathmin (STMN1) upregulated when compared to other B cell clusters show these have more of a proliferating signature, which points to dark zone B cells.
Inherited from celltype
- Set of Labels Description
- In this paper we used an automated iterative subclustering algorithm to find hundreds of cell state clusters, after which we merged unsupported clusters and annotated each resulting cluster with a better-known cell subtype. The high-res cell state clusters are annotated as subtype.gene1.gene2, so in some cases we didn't directly name some commonly named subtypes, such as pericytes. When we run DE on the resulting subtypes, we find many canonical and scRNA-suggested marker genes.
- Annotation Method
- both
- Algorithm Name
- ARBOL
- Algorithm Version
- v1.0
- Algorithm URL
- https://github.com/jo-m-lab/ARBOL/
