Endth/Lymph
- Ontology Term
- endothelial cell of lymphatic vesselCL:0002138
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- LEC, lymphatic endothelial cell
- CategoryClass of which the cell type is a subclass.
- endothelial cellCL:0000115
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CLDN5, LYVE1
- Rationale
- This cluster does not differentially express PECAM1, PLVAP, or VWF, but does have some claudin CLDN5 expression. It also expresses VIM, which points to fibroblasts, but one of the highest DE genes is LYVE1 - a gene recently suggested as a lymphatic vessel endothelial cell marker (see doi)
Inherited from celltype
- Set of Labels Description
- In this paper we used an automated iterative subclustering algorithm to find hundreds of cell state clusters, after which we merged unsupported clusters and annotated each resulting cluster with a better-known cell subtype. The high-res cell state clusters are annotated as subtype.gene1.gene2, so in some cases we didn't directly name some commonly named subtypes, such as pericytes. When we run DE on the resulting subtypes, we find many canonical and scRNA-suggested marker genes.
- Annotation Method
- both
- Algorithm Name
- ARBOL
- Algorithm Version
- v1.0
- Algorithm URL
- https://github.com/jo-m-lab/ARBOL/
