Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

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Cell Metadata

Plsma/IgA

Ontology Term: IgA plasma cellCL:0000987
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: IgA+ Plasma Cells
Category Class of which the cell type is a subclass.: IgA plasma cellCL:0000987
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: JCHAIN, IGHA2, IGHA1
Canonical Marker Genes: IGHA, JCHAIN, HLA
Rationale: Clear plasma cells with diversity of immunoglobulin transcript expression, but with higher IGHA

Set of Labels Description: In this paper we used an automated iterative subclustering algorithm to find hundreds of cell state clusters, after which we merged unsupported clusters and annotated each resulting cluster with a better-known cell subtype. The high-res cell state clusters are annotated as subtype.gene1.gene2, so in some cases we didn't directly name some commonly named subtypes, such as pericytes. When we run DE on the resulting subtypes, we find many canonical and scRNA-suggested marker genes.
Annotation Method: both
Algorithm Name: ARBOL
Algorithm Version: v1.0
Algorithm URL: https://github.com/jo-m-lab/ARBOL/

Ontology Term: IgA plasma cellCL:0000987
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: IgA+ Plasma Cells
Category Class of which the cell type is a subclass.: IgA plasma cellCL:0000987
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: JCHAIN, IGHA2, IGHA1
Canonical Marker Genes: IGHA, JCHAIN, HLA
Rationale: Clear plasma cells with diversity of immunoglobulin transcript expression, but with higher IGHA

Set of Labels Description: In this paper we used an automated iterative subclustering algorithm to find hundreds of cell state clusters, after which we merged unsupported clusters and annotated each resulting cluster with a better-known cell subtype. The high-res cell state clusters are annotated as subtype.gene1.gene2, so in some cases we didn't directly name some commonly named subtypes, such as pericytes. When we run DE on the resulting subtypes, we find many canonical and scRNA-suggested marker genes.
Annotation Method: both
Algorithm Name: ARBOL
Algorithm Version: v1.0
Algorithm URL: https://github.com/jo-m-lab/ARBOL/