Mac/cDC1
- Ontology Term
- conventional dendritic cellCL:0000990
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- cDC, dendritic reticular cell, DC1, type 1 DC, veiled cell, interdigitating cell, cDC1
- CategoryClass of which the cell type is a subclass.
- myeloid cellCL:0000763
- Canonical Marker Genes
- XCR1
- Rationale
- This small cluster expresses CD86, a dendritic cell marker, and many proliferative markers like STMN1, CENPF, and UBE2C, but not XCR1. It's possible it could be a cDC1 or more generally a proliferative dendritic cell despite lack of XCR1. Here it is grouped in with macrophages because it could be some kind of dendritic precursor but I'm not sure about this.
Inherited from celltype
- Set of Labels Description
- In this paper we used an automated iterative subclustering algorithm to find hundreds of cell state clusters, after which we merged unsupported clusters and annotated each resulting cluster with a better-known cell subtype. The high-res cell state clusters are annotated as subtype.gene1.gene2, so in some cases we didn't directly name some commonly named subtypes, such as pericytes. When we run DE on the resulting subtypes, we find many canonical and scRNA-suggested marker genes.
- Annotation Method
- both
- Algorithm Name
- ARBOL
- Algorithm Version
- v1.0
- Algorithm URL
- https://github.com/jo-m-lab/ARBOL/
