- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- cytotoxic lymphocyte
- CategoryClass of which the cell type is a subclass.
- lymphocyteCL:0000542
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CCL4, NKG7, CCL5, GZMA, CCL4L2, KLRD1, TRDC, GZMK, CD69
- Canonical Marker Genes
- NKG2D, CD8A, CD8B, KLRG1, KRLD1
- Rationale
- These are a cluster. of cytotoxic lymphocytes that are hard to categorize as either T or NK cells (or NKT for that matter). They display markers for both lineages, including T cell receptor subunit C TRDC as well as many NK markers such as KLRD1, and they display generally activated cytotoxic markers in high relative abundance - CCL4, CD69, GZMA/K, and NKG7