- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- M cell, M-cell, microfold cell
- CategoryClass of which the cell type is a subclass.
- epithelial cellCL:0000066
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- KRT8, MARCKSL1, CCL20, SPIB, NFKBIA
- Canonical Marker Genes
- SPIB, GP2, TNFAIP2, CCL9
- Rationale
- This is an epithelial subset (KRT8+) that shares some traits with the other secretory clusters, such as MARCKSL1, but one of its highest DE genes compared to other epithelial cells is CCL20, which is a maturation marker for M cells in the lymphoid follicle associated epithelia. It also expresses SPIB, a canonical marker of M cells It also expresses some TNF receptor signaling proteins, such as NFKBIA. These could be maturing follicle associated M cells or mature M cells, we are not sure.