Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

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Cell Metadata

cell_type

F4: TNN+COCH+

Full Name: Hair-follicle associated (TNN+COCH+)
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: COCH, CRABP1, COL24A1, RSPO4, SLITRK6, NRG3, MKX, TNMD
Canonical Marker Genes: unknown
Rationale: Note the same description is used for both F4: DP HHIP+ and F4: TNN+COCH+ due to uncertainty We named dermal papilla (F4: DP HHIP+) based on expression of reported dermal papilla markers (WNT5A, HHIP, RSPO3).(Rendl, Polak, and Fuchs 2008) However, we note that previous studies (e.g. 10.1101/2023.10.29.563503) have named the F4: TNN+COCH+ as dermal papilla with expression of CRABP1/COCH/RSPO4.We observed that the F4: DP HHIP+ population expressed CRABP1/COCH/RSPO4, at a lower level, but additionally expressed reported dermal papilla markers such as BMP7, RSPO3, and HHIP.(Hagner et al. 2020; Rendl, Polak, and Fuchs 2008) One possibility is that it represent dermal papilla in different states (e.g. anagen vs catagen). The F4: TNN+COCH+ population expressed relatively high universal fibroblast markers (CD34, PI16) and could thus represent a precursor population. Additionally, the F4: TNN+COCH+ population expressed genes reported for tendon-forming fibroblasts (MKX, TNMD).(Huang, Lu, and Schweitzer 2015)
Rationale DOI: 10.1101/gad.1614408 10.1101/2023.10.29.563503 10.1016/j.isci.2020.101019 10.1002/jor.22834

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual

F4: TNN+COCH+

Full Name: Hair-follicle associated (TNN+COCH+)
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: COCH, CRABP1, COL24A1, RSPO4, SLITRK6, NRG3, MKX, TNMD
Canonical Marker Genes: unknown
Rationale: Note the same description is used for both F4: DP HHIP+ and F4: TNN+COCH+ due to uncertainty We named dermal papilla (F4: DP HHIP+) based on expression of reported dermal papilla markers (WNT5A, HHIP, RSPO3).(Rendl, Polak, and Fuchs 2008) However, we note that previous studies (e.g. 10.1101/2023.10.29.563503) have named the F4: TNN+COCH+ as dermal papilla with expression of CRABP1/COCH/RSPO4.We observed that the F4: DP HHIP+ population expressed CRABP1/COCH/RSPO4, at a lower level, but additionally expressed reported dermal papilla markers such as BMP7, RSPO3, and HHIP.(Hagner et al. 2020; Rendl, Polak, and Fuchs 2008) One possibility is that it represent dermal papilla in different states (e.g. anagen vs catagen). The F4: TNN+COCH+ population expressed relatively high universal fibroblast markers (CD34, PI16) and could thus represent a precursor population. Additionally, the F4: TNN+COCH+ population expressed genes reported for tendon-forming fibroblasts (MKX, TNMD).(Huang, Lu, and Schweitzer 2015)
Rationale DOI: 10.1101/gad.1614408 10.1101/2023.10.29.563503 10.1016/j.isci.2020.101019 10.1002/jor.22834

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual