Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

F4: DP_HHIP+

Ontology Term

hair follicle dermal papilla cellCL:0000346

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

skin fibroblastCL:0002620

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

CRABP1, COL24A1, RSPO4, RSPO3, BMP7, WNT5A, LEF1, SOX18, HHIP

Canonical Marker Genes

BMP7, HHIP, RSPO4

Rationale

Note the same description is used for both F4: DP HHIP+ and F4: TNN+COCH+ due to uncertainty We named dermal papilla (F4: DP HHIP+) based on expression of reported dermal papilla markers (WNT5A, HHIP, RSPO3).(Rendl, Polak, and Fuchs 2008) However, we note that previous studies (e.g. 10.1101/2023.10.29.563503) have named the F4: TNN+COCH+ as dermal papilla with expression of CRABP1/COCH/RSPO4.We observed that the F4: DP HHIP+ population expressed CRABP1/COCH/RSPO4, at a lower level, but additionally expressed reported dermal papilla markers such as BMP7, RSPO3, and HHIP.(Hagner et al. 2020; Rendl, Polak, and Fuchs 2008) One possibility is that it represent dermal papilla in different states (e.g. anagen vs catagen). For example, LEF1 is only high in F4: DP_HHIP+. The F4: TNN+COCH+ population expressed relatively high universal fibroblast markers (CD34, PI16) and could thus represent a precursor population. Additionally, the F4: TNN+COCH+ population expressed genes reported for tendon-forming fibroblasts (MKX, TNMD).(Huang, Lu, and Schweitzer 2015)

Rationale DOI

10.1016/j.isci.2020.10101910.1101/2023.10.29.56350310.1101/gad.161440810.1002/jor.22834

Inherited from cell_type

Set of Labels Description

Aim to harmonise skin fibroblast labels across studies in both health and disease.

Annotation Method

manual