- Full Name
- CCL19+ Immune-interacting (fibroblast reticular-like cell)
- Closest Ontology Term
- fibroblastic reticular cellCL:0009101
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- unknown
- CategoryClass of which the cell type is a subclass.
- fibroblastic reticular cellCL:0009101
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CCL19, CD74, CH25H, TNFSF13B, IL33, HLA-DRA, IRF8, COX4I2, RBP5, ADAMDEC1, CXCL9, CXCL10, APOE, CXCL12
- Rationale
- The F3: CCL19+ Immune-interacting population was characterised by expression of genes associated with T-reticular cells (specialised fibroblasts in lymphoid organs), including genes involved in the segregation of immune cells (CCL19, CH25H), maintenance of immune cell niches (IL33, TNFSF13B), and antigen presentation (MHC-II molecules , CD74 (Supplementary figure 1f)).(Lütge, Pikor, and Ludewig 2021) T-reticular cells modulate T-cell location and activity in lymphoid organs/structures,(Lütge, Pikor, and Ludewig 2021) suggesting a similar role for F3 fibroblasts in skin.
This population also shared additional genes with F2/F3 bridge, including CXCL12, APOE, and PLA2G2A. PLA2G2A has been reported to marker a fibroblast population in cancer. APOE has been used. todescribe immune-interacting/inflammatory fibroblasts in skin more broadly.
These fibroblasts were enriched in Tcell regions in our data.
