Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

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Cell Metadata

F5: NGFR+

Full Name: Schwann-like fibroblast (NGFR+)
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: NGFR, TM4SF1, SFRP4, ANGPTL7, ITGA6, CDH19, CLDN1, EBF2, OLFM2, SCN7A
Canonical Marker Genes: unknown
Rationale: F5: Schwann-like fibroblasts were named as they expressed Schwann cell-markers, including SCN7A and ITGA6. Fibroblasts are known to be located in the endoneurium and perineurium,(Richard et al. 2014) and nerve-associated fibroblasts (ITGA6+EBF2+) have previously been described in skin and lung using scRNA- seq data.(Fiskin et al. 2023; Madissoon et al. 2022) To confirm a distinction to Schwann cells, we showed that Schwann cells and F5 fibroblasts clustered separately and clear gene expression differences were evident between these two populations.
Rationale DOI: 10.1101/2023.10.29.563503 10.1038/s41588-022-01243-4 10.1369/0022155414530994

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual

Full Name: Schwann-like fibroblast (NGFR+)
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: NGFR, TM4SF1, SFRP4, ANGPTL7, ITGA6, CDH19, CLDN1, EBF2, OLFM2, SCN7A
Canonical Marker Genes: unknown
Rationale: F5: Schwann-like fibroblasts were named as they expressed Schwann cell-markers, including SCN7A and ITGA6. Fibroblasts are known to be located in the endoneurium and perineurium,(Richard et al. 2014) and nerve-associated fibroblasts (ITGA6+EBF2+) have previously been described in skin and lung using scRNA- seq data.(Fiskin et al. 2023; Madissoon et al. 2022) To confirm a distinction to Schwann cells, we showed that Schwann cells and F5 fibroblasts clustered separately and clear gene expression differences were evident between these two populations.
Rationale DOI: 10.1101/2023.10.29.563503 10.1038/s41588-022-01243-4 10.1369/0022155414530994

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual