- Full Name
- Myofibroblast inflammatory
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- MFB
- CategoryClass of which the cell type is a subclass.
- skin fibroblastCL:0002620
- Rationale
- In addition to the classical myofibroblast signature (see F6: Myofibroblast), e). we distinguished F6: Myofibroblast chemokine-high from F6: Myofibroblasts based on expression of genes encoding chemokines (CXCL13, CXCL5, CXCL6, CXCL8) and interleukins (IL11, IL24) .
There was heterogentity in the F6: Myofibroblast chemokine-high/inflammatory population in different diseases. F6: Myofibroblast chemokine-high cells tended to have high expression of IL11, IL24, CXCL6, CXCL8, CXCL13, and WNT2 in a subset of diseases of groups: inflammatory with risk of scarring (hidradenitis supparativa, acne) or cancer (basal cell carcinoma, squamous cell carcinoma). Interestingly, IL-11 is a reported driver of fibrosis in mouse models (Ng et al. 2020; Schafer et al. 2017) and potentially cancer pathogenesis.(Widjaja et al. 2024) IL-24 has recently been described as a tissue injury sensing and repair pathway distinct from host pathogen defense.(Liu et al. 2023) While IL11+IL24+ CXCL5+CXCL13+WNT2+ fibroblasts have not been reported in prior human cross-tissue atlases,(Buechler et al. 2021; Korsunsky et al. 2022) IL11+IL24+ inflammatory-associated fibroblasts have been characterised in human inflammatory bowel disease.(Smillie et al. 2019) Marker genes of these inflammatory-associated fibroblasts were highly expressed in F6: Myofibroblast chemokine-high fibroblasts. These results suggest that IL11+IL24+ CXCL5+CXCL13+WNT2+ fibroblasts are a novel cross-tissue fibroblast population. The IL11+IL24+ CXCL5+CXCL13+WNT2+ signature was not observed in mouse data (all tissue) (Supplementary figure 4f).
