Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

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Cell Metadata

cell_type

F2: Universal

Full Name: Universal fibroblast
Closest Ontology Term: fibroblastCL:0000057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Steady-state like fibroblast
Category Class of which the cell type is a subclass.: skin fibroblastCL:0002620
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PI16, DPP4, PCOLCE2, MFAP5, CD70, LGR5
Canonical Marker Genes: PI16, CD34, PCOLCE2, DPP4
Rationale: The F2: Universal population expressed marker genes of ”Universal” PI16+ fibroblasts, including PI16, CD34, and DPP4.(Buechler et al. 2021) ”Universal” fibroblasts have been identified across multiple different tissues. They are also known as ”adventitial stromal cells/fibroblasts”, ”interstitial stromal cells”, and ”steady-state like fibroblasts”. It has been proposed that these cells may represent a precursor fibroblast cell state, but this remains uncertain.(McCartney, Chung, and Buechler 2024; Zhu et al. 2024) The location corresponds to reticular fibroblasts and "reticular fibroblast" markers mark this population (e.g. MFAP5). However, the universal gene signature is observed across tissue (see DOI links). Fascial fibroblasts also express many F2: Universal markers, but additionally express unique marker genes such as ITGA10 and the known fascial marker CCN3 (NOV3)
Rationale DOI: 10.1038/s41586-021-03549-5 10.12688/f1000research.143511.2

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual

F2: Universal

Full Name: Universal fibroblast
Closest Ontology Term: fibroblastCL:0000057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: Steady-state like fibroblast
Category Class of which the cell type is a subclass.: skin fibroblastCL:0002620
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PI16, DPP4, PCOLCE2, MFAP5, CD70, LGR5
Canonical Marker Genes: PI16, CD34, PCOLCE2, DPP4
Rationale: The F2: Universal population expressed marker genes of ”Universal” PI16+ fibroblasts, including PI16, CD34, and DPP4.(Buechler et al. 2021) ”Universal” fibroblasts have been identified across multiple different tissues. They are also known as ”adventitial stromal cells/fibroblasts”, ”interstitial stromal cells”, and ”steady-state like fibroblasts”. It has been proposed that these cells may represent a precursor fibroblast cell state, but this remains uncertain.(McCartney, Chung, and Buechler 2024; Zhu et al. 2024) The location corresponds to reticular fibroblasts and "reticular fibroblast" markers mark this population (e.g. MFAP5). However, the universal gene signature is observed across tissue (see DOI links). Fascial fibroblasts also express many F2: Universal markers, but additionally express unique marker genes such as ITGA10 and the known fascial marker CCN3 (NOV3)
Rationale DOI: 10.1038/s41586-021-03549-5 10.12688/f1000research.143511.2

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual