Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

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Cell Metadata

F2/3: Bridge

Full Name: Bridge immune-interacting
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: CXCL12, APOE, C7, PLA2G2A, EFEMP1, GDF10, MYOC
Canonical Marker Genes: unknown
Rationale: The F2/F3: Bridge was named as the population shared markers with F2 and F3 fibroblasts (Figure 1c), including genes associated with T-cell infiltration and activity (CXCL12, PLA2G2A).(Ge et al. 2023) Total transcript counts were similar between fibroblast populations and doublets were removed during pre-processing, suggesting it was not a composite population. In elderly patients, we observed a subset of F2/F3: Bridge fibroblasts with high expression of GDF10, MYOC, and PPARG. In adipocyte tissue, two types of fibroblast precursor are reported.
Rationale DOI: 10.1016/j.canlet.2023.216095

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual

Full Name: Bridge immune-interacting
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: CXCL12, APOE, C7, PLA2G2A, EFEMP1, GDF10, MYOC
Canonical Marker Genes: unknown
Rationale: The F2/F3: Bridge was named as the population shared markers with F2 and F3 fibroblasts (Figure 1c), including genes associated with T-cell infiltration and activity (CXCL12, PLA2G2A).(Ge et al. 2023) Total transcript counts were similar between fibroblast populations and doublets were removed during pre-processing, suggesting it was not a composite population. In elderly patients, we observed a subset of F2/F3: Bridge fibroblasts with high expression of GDF10, MYOC, and PPARG. In adipocyte tissue, two types of fibroblast precursor are reported.
Rationale DOI: 10.1016/j.canlet.2023.216095

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual