Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

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Cell Metadata

cell_type

F1: Superficial

Full Name: Superficial fibroblast
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: APCDD1, COL18A1, COL23A1, COMP, NKD2, WIF1, RSPO1, AXIN2
Canonical Marker Genes: unknown
Rationale: The F1: Superficial population was characterised by expression of genes encoding collagens found in the superficial dermis (COL13A1, COL18A1, COL23A1)(Philippeos et al. 2018; Solé-Boldo et al. 2020) and WNT inhibitors (APCDD1, WIF1, and NKD2). Expression of WNT signalling components is also characteristic of superficial intestinal fibroblasts. The location of these fibroblasts was adjacent to epidermis. . In agreement with this location, current evidence points towards a WNT-mediated, synergistic interplay between superficial fibroblasts and basal keratinocytes that is essential for the maintenance of fibroblast cellular identity in skin.(Knoedler et al. 2023; Philippeos et al. 2018; Rognoni et al. 2016) A fibroblast population expressing Wnt signalling inhibitors (Sfrp2, Axin2, Wif1) and Wnt5a (similar to F1: Superficial regenerative fibroblasts) has also been linked to an anti-fibrotic phenotype in murine heart tissue.(Farbehi et al. 2019)
Rationale DOI: 10.1016/j.jid.2018.01.016 10.1038/s42003-020-0922-4 10.3389/fimmu.2023.1233800 10.1242/dev.131797 10.7554/eLife.43882.

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual

F1: Superficial

Full Name: Superficial fibroblast
Closest Ontology Term: skin fibroblastCL:0002620
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: unknown
CategoryClass of which the cell type is a subclass.: skin fibroblastCL:0002620
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: APCDD1, COL18A1, COL23A1, COMP, NKD2, WIF1, RSPO1, AXIN2
Canonical Marker Genes: unknown
Rationale: The F1: Superficial population was characterised by expression of genes encoding collagens found in the superficial dermis (COL13A1, COL18A1, COL23A1)(Philippeos et al. 2018; Solé-Boldo et al. 2020) and WNT inhibitors (APCDD1, WIF1, and NKD2). Expression of WNT signalling components is also characteristic of superficial intestinal fibroblasts. The location of these fibroblasts was adjacent to epidermis. . In agreement with this location, current evidence points towards a WNT-mediated, synergistic interplay between superficial fibroblasts and basal keratinocytes that is essential for the maintenance of fibroblast cellular identity in skin.(Knoedler et al. 2023; Philippeos et al. 2018; Rognoni et al. 2016) A fibroblast population expressing Wnt signalling inhibitors (Sfrp2, Axin2, Wif1) and Wnt5a (similar to F1: Superficial regenerative fibroblasts) has also been linked to an anti-fibrotic phenotype in murine heart tissue.(Farbehi et al. 2019)
Rationale DOI: 10.1016/j.jid.2018.01.016 10.1038/s42003-020-0922-4 10.3389/fimmu.2023.1233800 10.1242/dev.131797 10.7554/eLife.43882.

Inherited from cell_type

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual