Skin fibroblasts - Pan-disease fibroblast atlas in skin fibrosis, inflammation, and cancer

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Cell Metadata

F4: DS_DPEP1+

Full Name: Dermal sheath_DPEP1+ (hair-follicle associated)
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: skin fibroblastCL:0002620
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MEF2C, MYL4, COL11A1, POSTN, DPEP1
Canonical Marker Genes: DPEP1, MYL4,
Rationale: The F4: DS DPEP1+ population expressed markers which correspond to a well-defined dermal sheath population previously (DPEP1, MEF2C, and MYL4);(Ahlers et al. 2021) . POSTN also markers this population in health. However, POSTN is upregulated by many fibroblast subpopulations.in disease.
Rationale DOI: 10.3389/fgene.2021.797747

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual

Full Name: Dermal sheath_DPEP1+ (hair-follicle associated)
Closest Ontology Term: skin fibroblastCL:0002620
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: skin fibroblastCL:0002620
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MEF2C, MYL4, COL11A1, POSTN, DPEP1
Canonical Marker Genes: DPEP1, MYL4,
Rationale: The F4: DS DPEP1+ population expressed markers which correspond to a well-defined dermal sheath population previously (DPEP1, MEF2C, and MYL4);(Ahlers et al. 2021) . POSTN also markers this population in health. However, POSTN is upregulated by many fibroblast subpopulations.in disease.
Rationale DOI: 10.3389/fgene.2021.797747

Set of Labels Description: Aim to harmonise skin fibroblast labels across studies in both health and disease.
Annotation Method: manual