- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- lymph node centrocyte, Light Zone Germinal Center B cell
- CategoryClass of which the cell type is a subclass.
- germinal center B cellCL:0000844
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CD83, LMO2, RGS13, MEF2B, BCL2A1
- Canonical Marker Genes
- CD83, LMO2, RGS13, BCL2A1
- Rationale
- Cells in this cluster show expression of well-known light zone markers, i.e. CD83, LMO2, and downregulation of DZ genes such as CXCR4 or AICDA. Within this cluster, genes related to CD40 signaling and response to BCR stimulation are starting to be expressed (e.g. BCL2A1, BCL2L1, TRAF1/4 or EBI3). However, the expression levels of these genes were not homogeneous, suggesting the presence of different levels of activation of LZ cells.