- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- lymph node centroblast, DZ GCB, DZ Germinal Center B cells
- CategoryClass of which the cell type is a subclass.
- germinal center B cellCL:0000844
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- SUGCT, AICDA, CXCR4, MME, CD38
- Canonical Marker Genes
- CXCR4, AICDA, MME
- Rationale
- Cluster with high expression of CXCR4 (a marker defining DZ GCB cells) and additional expression of DZ markers, such as FOXP1 and MME, as well as moderate expression of AICDA. Cells from these clusters are clearly non-proliferative, lacking the detectable expression of any cell cycle gene. Therefore, we hypothesize that cells in this cluster, although they maintain the expression of dark zone-related genes, have already finished the cell cycle program and are progressing towards the next maturation stage. (Bar-Joseph et al., 2008; Holmes et al., 2020; King et al., 2021; Milpied et al., 2018)