- Full Name
- Activated B cell
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- B-cell, B-lymphocyte, B lymphocyte
- CategoryClass of which the cell type is a subclass.
- B cellCL:0000236
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- FCER2, IGHD, NFKB2, REL, CD69, MYC, CD83, EGR3, CCL3
- Canonical Marker Genes
- FCER2, IGHD, NFKB2, REL, CD69, MYC, CD83, EGR3, CCL3
- Rationale
- Cells in this cluster express typical NBC markers such as FCER2 (CD23), TCLA1, IGHM and IGHD. This cluster is characterized by the expression of very specific genes that seem to correspond to activation and early GC commitment due to the transient MYC upregulation (Dominguez-Sola et al., 2012). For instance, we observed high expression of EGR family (i.e. EGR1, EGR2, EGR3), transcription factors that are rapidly induced upon stimulation of the BCR genes (Gururajan et al., 2008) related to NF-kB pathway (i.e. NFKB1, NFKB2, NFKBIA, NFKBID, RELB) (Burger and Chiorazzi, 2013); or proinflammatory chemokines i.e. CCL3 and CCL4 (Takahashi et al., 2015) . Furthermore, in this cluster we identified high levels of bone-fide activation marker, i.e. CD69 (Cibrián and Sánchez-Madrid, 2017).