- Full Name
- CD4 T follicular helper memory cells
- Closest Ontology Term
- T follicular helper cellCL:0002038
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- T(FH) memory, follicular helper memory T cell, Tfh memory
- CategoryClass of which the cell type is a subclass.
- T cellCL:0000084
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CD3D, CD3E, KLRB1, MAF, TOX2, ICOS, IL21
- Canonical Marker Genes
- CD3D, CD3E, KLRB1, MAF, TOX2, ICOS, IL21, CD4
- Rationale
- Upon leaving a GC, the Tfh cell acquires a less activated, less polarized Tfh phenotype and can upregulate KLRB1 and develop into resting memory Tfh cells. This cluster had the expression of follicular markers PDCD1, MAF, and higher expression of memory markers such as KLRB1, ITGB1, and CD28