- Full Name
- CD4 central memory T cell
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- memory T lymphocyte, memory T-lymphocyte, memory T-cell, CM CD4 T cell
- CategoryClass of which the cell type is a subclass.
- T cellCL:0000084
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CD3D, CD3G, IL7R, TCF7, ANXA1, ANK3, PASK, S100A4
- Canonical Marker Genes
- CD3D, CD3G, IL7R, TCF7, ANXA1, PASK, S100A4
- Rationale
- After antigen encounter T cells acquire memory and effector functions maintaining the lymph node homing. CM showed an upregulation of IL7R compared to naïve T cells, and higher expression of PRDM1, PASK, ANXA1 and S100A4. They had an intermediate expression of CCR7 and higher expression of CD28 confirming their migratory capacity to secondary lymph nodes and their memory profile based on their effector function. This cluster expressed CD45RO at the protein level.