- Full Name
- CD8 central memory T cell
- Closest Ontology Term
- CD4-positive, alpha-beta memory T cell, CD45RO-positiveCL:0001204
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- CD4-positive, alpha-beta memory T-cell, CD45RO-positive, CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive, CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive
- CategoryClass of which the cell type is a subclass.
- T cellCL:0000084
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CD3D, CD3E, CD8A, CD8B, IL7R, ANXA1, S100A4
- Canonical Marker Genes
- CD3D, CD3E, CD8A, CD8B, IL7R, ANXA1, S100A4
- Rationale
- CM CD8 T cells acquire memory (marked by IL7R+) while maintaining lymph node homing capacity (CCR7+). CM CD8 T cells expressed higher levels of IL7R compared to naïve T cells, and higher expression of ANXA1 and S100A4. They had an intermediate expression of CCR7 and a higher expression of CD28. At the protein level, this cluster was CD45RO+, and CD28+.
This cluster has a very similar gene expression profile to CD4 TCM. While CD4 transcripts are usually not detected in scRNA-seq data, both CD8A and CD8B are detectable and used to differentiate both cell types.