CD8 TCM
- Full Name
- CD8 central memory T cell
- Closest Ontology Term
- CD4-positive, alpha-beta memory T cell, CD45RO-positiveCL:0001204
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- CD4-positive, alpha-beta memory T-cell, CD45RO-positive, CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive, CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive
- CategoryClass of which the cell type is a subclass.
- T cellCL:0000084
- Rationale
- CM CD8 T cells acquire memory (marked by IL7R+) while maintaining lymph node homing capacity (CCR7+). CM CD8 T cells expressed higher levels of IL7R compared to naïve T cells, and higher expression of ANXA1 and S100A4. They had an intermediate expression of CCR7 and a higher expression of CD28. At the protein level, this cluster was CD45RO+, and CD28+.
This cluster has a very similar gene expression profile to CD4 TCM. While CD4 transcripts are usually not detected in scRNA-seq data, both CD8A and CD8B are detectable and used to differentiate both cell types.
Inherited from cell_type_azimuth
- Set of Labels Description
- The annotation provided in this first version comprises 42 categories that provide a stable categories to classify single-cell transcriptomes of SLOs, useful for tools like Azimuth (see external URLs). In the next version, we will add a more detailed classification, encompassing all cell types and states identified in the tonsil atlas. A validation cohort was included to confirm the presence and accuracy of each annotation this latter level, using criteria such as cell neighborhood preservation, conservation of bona fide marker genes, and annotation confidence derived from the KNN classifier. For a full description and interpretation of this validation cohort, please refer to the final section of the manuscript.
- Annotation Method
- manual
