- Full Name
- tonsil epithelial cell
- Closest Ontology Term
- tonsil squamous cellCL:1001577
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- tonsil squamous epithelial cells, tonsillar squamous cell, tonsil squamous epithelial cell, tonsillar squamous epithelial cell, tonsillar epithelial cell
- CategoryClass of which the cell type is a subclass.
- epithelial cellCL:0000066
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- KRT19, KRT13, KRT18, KRT14, KRT5, LCE3D, SPINK5, SPRR3, SPRR1B
- Canonical Marker Genes
- KRT19, KRT13, KRT18, KRT14, KRT5, LCE3D, SPINK5, SPRR3, SPRR1B
- Rationale
- This cluster represents the epithelial cells of the tonsil, characterized by the expression of several cytokeratins (e.g. KRT5, KRT19).
In version 2.0, we will further stratify it into basal, surface, outer surface and crypt layers.
One of these clusters expressed FDCSP (FDCSP epithelium). FDCSP was first described in FDC and in ‘‘leukocyte-infiltrated tonsillar crypts,’’ although the specific population within the crypts remained unknown. We provide evidence that FDSCP-expressing cells represent a specific subpopulation of the tonsillar epithelium, in line with a cluster observed in the oral mucosa cell atlas.