- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- unknown
- CategoryClass of which the cell type is a subclass.
- dendritic cellCL:0000451
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- LYZ, CST3, LGALS3, FCER1A, CLEC9A, SIGLEC10
- Canonical Marker Genes
- LYZ, CST3, LGALS3, FCER1A, CLEC9A, SIGLEC10
- Rationale
- The dendritic cell subsets described in the tonsil atlas overlap with the ones provided by Villani, et al. (2017) in peripheral blood: DC1, conventional DC1 (cDC1, e.g. CLEC9A), divided into precursor and mature states on
the basis of XCR1 expression (Balan et al., 2018); (2) DC2 and DC3, corresponding to cDC2
(CD1C, FCER1A, CLEC10A) and differing in their antigen-presenting capacity (e.g. HLA-DQB1)
and inflammatory signatures (S100A8, S100A9), respectively; (3) DC4 (FCGR3A, SERPINA1 and
FTL) putatively derive from non-classical monocytes; and (4) DC5 expressing AXL and SIGLEC6
(AS), the hallmark markers of AS DCs
These subsets will be available in version 2.0.