- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- memory B-cell, memory B-lymphocyte, memory B lymphocyte
- CategoryClass of which the cell type is a subclass.
- B cellCL:0000236
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CD27, BANK1, MARCH1, TNFRSF13B, BLK, CD24
- Canonical Marker Genes
- CD19, CD27, TNFRSF13B, CD24
- Rationale
- Memory B cells are a vital subset of the adaptive immune system, distinguished by their long-lived nature and ability to persist for decades after initial antigen exposure. These cells circulate in a quiescent state and rapidly respond to re-exposure to their specific antigen, quickly differentiating into antibody-producing plasma cells, thereby ensuring a faster and more robust secondary immune response compared to naive B cells. They retain antigen specificity and can express various immunoglobulin isotypes, often originating from germinal centers in secondary lymphoid organs. Memory B cells are essential for long-term immunity and the effectiveness of vaccines.
They can be further stratified into class-switched (IgG+ or IgA+) or non-class switch (IgD or IgM), and they differ from naive B cells by the expression of CD27 and negativity for TCL1A and FCER2