- Full Name
- LZtoDZ GCB transition
- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- lymph node centrocyte, LZ-DZ GCBC, recycling centrocyte
- CategoryClass of which the cell type is a subclass.
- germinal center B cellCL:0000844
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- BATF, MYC, NME1, EBI3, LMO2
- Canonical Marker Genes
- BATF, MYC, NME1, EBI3, LMO2
- Rationale
- Cluster with high expression of CD83 and low expression of CXCR4, as well as positive for LMO2, which indicate that this cluster contains LZ-GCBC cells. Within this cluster, apart from the high expression of genes associated with the previously described LZ cluster, the cells start to express very specific genes such as MYC, MIR155HG or genes related to NF-kB pathway (i.e. NFKB1, NFKB2, NFKBIA, NFKBID, RELB). This transient expression of MYC and MYC targets (NME1) has been described in LZ cells re-entering into the DZ, to continue with additional rounds of affinity maturation (Dominguez-Sola et al., 2012). Additionally, as compared to the LZ cluster, this cluster shows higher expression of BATF, a gene known to be involved in regulating AIDCA (a DZ marker).