- SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.
- regulatory T-lymphocyte, regulatory T-cell, regulatory T lymphocyte, suppressor T cell, suppressor T lymphocyte, suppressor T-lymphocyte, Treg, suppressor T-cell, regulatory CD4 T cell
- CategoryClass of which the cell type is a subclass.
- T cellCL:0000084
- Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.
- CD3D, CD3E, CD2, CYTOR, IL10, FOXP3, CTLA4, IL2RA
- Canonical Marker Genes
- CD3D, CD3E, CD2, CD4, IL10, FOXP3, CTLA4, IL2RA
- Rationale
- CD4 T regulatory (Treg) cells are vital for the maintenance of immune tolerance, and are characterized by the expression of cytokine IL10, the transcription factor FOXP3 and the expression of IL2RA (CD25) and CTLA4.
In version 2.0, we will further subdivide this cluster into effector Tregs and T follicular regulatory cells.