Single-cell multi-omics analysis of the immune response in COVID-19

Summary

Single-cell transcriptome analysis of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19.

Metadata

Dataset Type

Integrated. The file includes an integrated collection of datasets.

Total Cells

647,366

organism

Homo sapiens

tissue

blood

assay

10x 3' transcription profiling

disease

COVID-19 (527,286 cells)normal (104,923 cells)respiratory system disorder (15,157 cells)

Cell Labels

cell_type (46)

647,366 cells

CD14-positive monocyte

120,843

CD16-positive, CD56-dim natural killer cell, human

92,848

naive thymus-derived CD4-positive, alpha-beta T cell

63,096

effector CD8-positive, alpha-beta T cell

53,534

central memory CD4-positive, alpha-beta T cell

49,904

naive B cell

44,136

naive thymus-derived CD8-positive, alpha-beta T cell

31,175

mature NK T cell

21,673

effector memory CD8-positive, alpha-beta T cell

18,917

T-helper 22 cell

18,379

gamma-delta T cell

15,942

platelet

15,847

T follicular helper cell

13,608

mucosal invariant T cell

10,992

CD16-negative, CD56-bright natural killer cell, human

10,442

class switched memory B cell

7,244

immature B cell

5,238

natural killer cell

4,963

plasmacytoid dendritic cell

4,612

CD14-low, CD16-positive monocyte

4,140

plasmablast

4,121

IgG plasma cell

3,527

dendritic cell, human

3,357

unswitched memory B cell

3,285

myeloid dendritic cell

3,243

B cell

3,024

IgA plasma cell

2,699

effector memory CD4-positive, alpha-beta T cell

2,634

malignant cell

2,291

CD34-positive, CD38-negative hematopoietic stem cell

2,238

erythrocyte

2,232

CD8-positive, alpha-beta T cell

1,355

IgM plasma cell

1,163

ILC1, human

776

erythroid progenitor cell, mammalian

773

monocyte

649

CD4-positive, alpha-beta T cell

624

dendritic cell

585

T-helper 1 cell

481

regulatory T cell

329

hematopoietic precursor cell

180

group 2 innate lymphoid cell, human

93

T-helper 2 cell

55

megakaryocyte

53

myeloid lineage restricted progenitor cell

53

T-helper 17 cell

13