Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

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Cell Metadata

Epi-TDC

Ontology Term: epithelial cellCL:0000066
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: epitheliocyte
CategoryClass of which the cell type is a subclass.: eukaryotic cellCL:0000255
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: ADIRF, KRT12, S100A4, PERP, ERICH5, ELF3, DAPL1, UPK3BL1, UPK1B, FXYD3
Canonical Marker Genes: unknown
Rationale: majorclass annotated by KRT5; from Epi-PMC, Epi-TDC/PMC, to Epi-TDC, KRT3 and KRT12 expression increase; 11.8% conjunctival basal epithelium+98.7% corneal basal epithelium+99.1% corneal superficial epithelium+99.5% corneal suprabasal epithelial cells+99.5% limbal superficial epithelium+94.7% limbal suprabasal epithelial cells from Lako adult dataset; 26.1% Conj+88.5% TDC from Chen dataset

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual

Ontology Term: epithelial cellCL:0000066
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: epitheliocyte
CategoryClass of which the cell type is a subclass.: eukaryotic cellCL:0000255
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: ADIRF, KRT12, S100A4, PERP, ERICH5, ELF3, DAPL1, UPK3BL1, UPK1B, FXYD3
Canonical Marker Genes: unknown
Rationale: majorclass annotated by KRT5; from Epi-PMC, Epi-TDC/PMC, to Epi-TDC, KRT3 and KRT12 expression increase; 11.8% conjunctival basal epithelium+98.7% corneal basal epithelium+99.1% corneal superficial epithelium+99.5% corneal suprabasal epithelial cells+99.5% limbal superficial epithelium+94.7% limbal suprabasal epithelial cells from Lako adult dataset; 26.1% Conj+88.5% TDC from Chen dataset

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual