Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

Main

Cell Metadata

Melanocytes

Ontology Term: melanocyteCL:0000148
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: melanophore
Category Class of which the cell type is a subclass.: pigment cellCL:0000147
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PMEL, TYRP1, MLANA, DCT, APOE, TRPM1, FMN1, EDNRB, PLEKHA5, MITF
Canonical Marker Genes: MLANA, TYR
Rationale: 94% MeC from Shi dataset;35.6% melanocytes from Lako adult dataset;97.6% melanocytes from Lako fetal dataset;96.1% MC from Chen dataset; ; majorclass annotated by MLANA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual

Ontology Term: melanocyteCL:0000148
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: melanophore
Category Class of which the cell type is a subclass.: pigment cellCL:0000147
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PMEL, TYRP1, MLANA, DCT, APOE, TRPM1, FMN1, EDNRB, PLEKHA5, MITF
Canonical Marker Genes: MLANA, TYR
Rationale: 94% MeC from Shi dataset;35.6% melanocytes from Lako adult dataset;97.6% melanocytes from Lako fetal dataset;96.1% MC from Chen dataset; ; majorclass annotated by MLANA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual