Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

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Cell Metadata

Corneal Stromal Keratocytes

Ontology Term: keratocyteCL:0002363
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: corneal fibroblast, corneal keratocyte
Category Class of which the cell type is a subclass.: neural crest derived fibroblastCL:0000005
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: DCN, PTGDS, APOD, ANGPTL7, ITGBL1, CST3, SAA1, KERA, COL12A1, SOD3
Canonical Marker Genes: KERA, ALDH3A1, MME
Rationale: 100% corneal stroma keratocytes+99.6% corneal stromal stem cells+18.1% limbal fibroblasts from Lako adult dataset; 30.7% corneal endothelium from Lako fetal dataset; majorclass annotated by DCN, high expression of KERA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual

Ontology Term: keratocyteCL:0002363
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: corneal fibroblast, corneal keratocyte
Category Class of which the cell type is a subclass.: neural crest derived fibroblastCL:0000005
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: DCN, PTGDS, APOD, ANGPTL7, ITGBL1, CST3, SAA1, KERA, COL12A1, SOD3
Canonical Marker Genes: KERA, ALDH3A1, MME
Rationale: 100% corneal stroma keratocytes+99.6% corneal stromal stem cells+18.1% limbal fibroblasts from Lako adult dataset; 30.7% corneal endothelium from Lako fetal dataset; majorclass annotated by DCN, high expression of KERA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual