Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

Main

Cell Metadata

Limbus/Sclera Fibroblasts - C1

Ontology Term: fibroblastCL:0000057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: connective tissue cellCL:0002320
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FBLN1, IGFBP5, MGP, TIMP3, LGALS1, PRELP, COL1A2, DCN, ID3, VIM
Canonical Marker Genes: unknown
Rationale: 81.1% limbal fibroblasts+100% limbal stroma keratocytes from Lako adult dataset;84.5% fibroblasts I+96.2% fibroblasts II+70% fibroblasts III+68% Limbal stroma+19% myofibroblasts+60% proliferating cells+97.1% proliferating corneal endothelium+11.4% proliferating progenitors+47.9% blood vessels+11.4% red blood cells from Lako fetal dataset; majorclass annotated by DCN; lower expression of KERA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual

Ontology Term: fibroblastCL:0000057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: connective tissue cellCL:0002320
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FBLN1, IGFBP5, MGP, TIMP3, LGALS1, PRELP, COL1A2, DCN, ID3, VIM
Canonical Marker Genes: unknown
Rationale: 81.1% limbal fibroblasts+100% limbal stroma keratocytes from Lako adult dataset;84.5% fibroblasts I+96.2% fibroblasts II+70% fibroblasts III+68% Limbal stroma+19% myofibroblasts+60% proliferating cells+97.1% proliferating corneal endothelium+11.4% proliferating progenitors+47.9% blood vessels+11.4% red blood cells from Lako fetal dataset; majorclass annotated by DCN; lower expression of KERA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual