Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

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Cell Metadata

Unknown Epithelium

Ontology Term: epithelial cellCL:0000066
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: epitheliocyte
Category Class of which the cell type is a subclass.: eukaryotic cellCL:0000255
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KRT12, DENND2C, KRT5, CLDN1, EZR, CLDN4, TACSTD2, MT-CO1, PERP, DSP
Canonical Marker Genes: unknown
Rationale: 22.8% conjunctival epithelium+17.1% corneal epithelium+23.5% limbal stem/progenitor cells from Lako fetal dataset; majorclass annotated by KRT5; not sure whether we should keep this cluster since it has relatively-lower nCount_RNA and nFeature_RNA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual

Ontology Term: epithelial cellCL:0000066
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: epitheliocyte
Category Class of which the cell type is a subclass.: eukaryotic cellCL:0000255
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KRT12, DENND2C, KRT5, CLDN1, EZR, CLDN4, TACSTD2, MT-CO1, PERP, DSP
Canonical Marker Genes: unknown
Rationale: 22.8% conjunctival epithelium+17.1% corneal epithelium+23.5% limbal stem/progenitor cells from Lako fetal dataset; majorclass annotated by KRT5; not sure whether we should keep this cluster since it has relatively-lower nCount_RNA and nFeature_RNA

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual