Single Cell Atlas of Human Ocular Surface scRNA-seq: Cornea, Limbus, Sclera

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Cell Metadata

Fetal Keratocytes

Ontology Term: keratocyteCL:0002363
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: corneal fibroblast, corneal keratocyte
Category Class of which the cell type is a subclass.: neural crest derived fibroblastCL:0000005
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL1A1, COL1A2, COL5A1, COL11A1, SPARC, COL14A1, COL5A2, COL3A1, OGN, THBS2
Canonical Marker Genes: KERA
Rationale: 99.8% corneal stroma keratocytes I+98.2% corneal stroma keratocytes II+99.7% corneal stroma keratocytes III+35.2% endothelial progenitors+15.3% fibroblasts I+29.6% fibroblasts III+99.3% keratocytes I+99.6% keratocytes II+99.8% keratocytes III+99.4% keratocytes IV+31.7% Limbal stroma+89.8% neural crest+18.9% proliferating cells+27.1% proliferating epithelial progenitors+80.8% proliferating progenitors+92.5% proliferating progenitors I+97.5% proliferating progenitors II+98.4% proliferating progenitors III+82.9% red blood cells+100% ciliary margin from Lako fetal dataset

Set of Labels Description: This atlas is an integrated collection of over 815k cells, derived from single-cell RNA-seq data of human ocular surface, including cornea, limbus, and anterior sclera. These cells have been categorized into 10 major cell classes and 31 types. This is the initial cell type label for the atlas annotation. These labels will be examined, refined, and updated during the annotation jamboree.
Annotation Method: manual