New Human Cell Atlas (HCA) published: Human Cell Atlas Kidney Atlas v1

We are excited to announce the release of the Human Cell Atlas Kidney (HCKA) v1, a comprehensive single-cell reference map of the human kidney across health and disease. The resource integrates approximately 1 million high-quality single-cell and single-nucleus transcriptomes collected from 18 datasets, comprising 258 samples and 232 donors spanning both sexes and a broad age range. HCKA includes both healthy tissue and multiple kidney diseases, including acute kidney injury (AKI), glomerulonephritis, transplant rejection, polycystic kidney disease, and diabetic kidney disease.

Using a benchmarked and harmonized analysis framework, HCKA defines 123 kidney cell populations and provides a high-resolution view of kidney cellular diversity and pathology. The resource captures cell types and cell states associated with both healthy and diseased kidneys and serves as a curated reference for cell type discovery, annotation, and cross-dataset comparison across single-cell and single-nucleus modalities.

The HCKA will continue to evolve as new datasets, technologies, and populations are incorporated, creating an expanding community resource for kidney biology and disease. We encourage the kidney and single-cell communities to contribute feedback and help refine annotations and cell state definitions as the atlas grows.

Access the Human Cell Atlas Kidney (HCKA): Human Cell Atlas Kidney