Human PBMC atlas - T CD8 effector and nonnaive cells and innate lymphoid cells including NK cells

T CD8 CTL ZNF683

Full Name: ZNF683+ CD8-positive, alpha-beta cytotoxic T cell
Closest Ontology Term: CD8-positive, alpha-beta cytotoxic T cellCL:0000794
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: CD8-positive, alpha-beta cytotoxic T cellCL:0000794
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Cluster with canonical cytotoxic markers (GZMA & GZMK) and ZNF683+
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ZNF683
Canonical Marker Genes: CD8, GZMA, GMZH
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Cluster with canonical cytotoxic markers (GZMA & GZMK) and ZNF683+
Rationale DOI: https://doi.org/10.1182/blood-2025-5086

Set of Labels Description: Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.
Annotation Method: manual