Achilles tendon atlas - muscle cells

Main

Cell Metadata

Fast-twitch skeletal muscle cells

Ontology Term: fast muscle cellCL:0000190
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: fast-twitch myofiber, type II fiber, glycolytic myofiber, white fiber
Category Class of which the cell type is a subclass.: skeletal muscle fiberCL:0008002
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYH2, MYH1, TNNT3, CKM
Canonical Marker Genes: MYH1, MYH2, TNNT3, MYL1
Rationale: This cell was annotated manually using canonical fast-twitch myofiber markers in the field (MYH2, MYH1, TNNT3, CKM).
Rationale DOI: https://doi.org/10.1038/s41467-020-18789-8 https://doi.org/10.1038/s41467-020-20064-9 https://doi.org/10.1038/s41467-020-20063-w https://doi.org/10.1016/j.celrep.2017.05.054 https://doi.org/10.1186/s13395-015-0046-6 https://doi.org/10.1038/s43587-024-00613-3

Set of Labels Description: Lineage annotations were determined by Louvain clustering at resolution 0.1. Each lineage (fibroblast, muscle, immune, stromal) was then subsetted and reclustered. Final annotation resolution was chosen according to expression of biological markers; smaller clusters were combined were appropriate
Annotation Method: manual

Ontology Term: fast muscle cellCL:0000190
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: fast-twitch myofiber, type II fiber, glycolytic myofiber, white fiber
Category Class of which the cell type is a subclass.: skeletal muscle fiberCL:0008002
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYH2, MYH1, TNNT3, CKM
Canonical Marker Genes: MYH1, MYH2, TNNT3, MYL1
Rationale: This cell was annotated manually using canonical fast-twitch myofiber markers in the field (MYH2, MYH1, TNNT3, CKM).
Rationale DOI: https://doi.org/10.1038/s41467-020-18789-8 https://doi.org/10.1038/s41467-020-20064-9 https://doi.org/10.1038/s41467-020-20063-w https://doi.org/10.1016/j.celrep.2017.05.054 https://doi.org/10.1186/s13395-015-0046-6 https://doi.org/10.1038/s43587-024-00613-3

Set of Labels Description: Lineage annotations were determined by Louvain clustering at resolution 0.1. Each lineage (fibroblast, muscle, immune, stromal) was then subsetted and reclustered. Final annotation resolution was chosen according to expression of biological markers; smaller clusters were combined were appropriate
Annotation Method: manual