Disagreements with any aspect of the Cell Ontology.
The 'T-lymphocyte' grouping includes NK/NKT cells (CL:0000623) alongside CD4+ and CD8+ T cells. NK cells are not strictly T lymphocytes; CL:0000084 (T cell) is used as the practical broad label for this lymphoid immune compartment.
Marker Gene Evidence
Gene markers used by researcher to assign this cell annotation.
Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.
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Rationale
The 'T-lymphocyte' group was identified and annotated by Austin Reed, encompassing CD4+ T cells, CD8+ T cells, and NK/NKT cells. CD3D, CD3E, and TRAC are canonical pan-T cell markers used for identification.
