Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

HRpos_Luminal (LHS)

Ontology Term: luminal hormone-sensing cell of mammary glandCL:4033058
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: HS-MEC, luminal hormone-responsive cell, luminal mature cell, hormone-sensing mammary epithelial cell, LumHR, LHS, hormone sensing cell, HS, ER-positive luminal hormone-sensor cell
Category Class of which the cell type is a subclass.: luminal epithelial cell of mammary glandCL:0002326
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ELF3, EPCAM, KRT18, KRT19, KRT8, MUC1, AGR2, ALCAM, ANKRD30A, AR, AREG, PIP, TFF1, TFF3, ESR1, PGR
Canonical Marker Genes: ESR1, PGR, AR, AREG, TFF1, TFF3, AGR2, ANKRD30A, PIP, ALCAM
Rationale: This cluster exhibits high transcriptional activity of nuclear hormone receptors (ESR1, PGR, AR), nuclear receptor-driven gene programs (TFF1, TFF3, AGR2) and paracrine signal mediators (AREG), combined with lineage-defining cytokeratins (KRT8, KRT18, KRT19). This co-expression profile identifies this population as mature hormone-responsive luminal epithelial cells. Unified nomenclature: luminal hormone-sensing (LHS) cell

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual