Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Secretory_Luminal (LASP)

Ontology Term

luminal adaptive secretory precursor cell of mammary glandCL:4033057

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

LASP, LP, alveolar progenitor, AP, LumSec, alveolar cell, luminal progenitor cell, ER-negative luminal alveolar progenitor, AV, luminal progenitor, luminal secretory cell

Category

Class of which the cell type is a subclass.

luminal epithelial cell of mammary glandCL:0002326

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

ELF3, EPCAM, KRT18, KRT19, KRT8, ALDH1A3, BBOX1, GABRP, KIT, KRT15, LTF, PROM1, SLPI

Canonical Marker Genes

EPCAM, KRT8, KRT18, KRT19, ALDH1A3, SLPI, GABRP

Rationale

This gene expression signature combines key luminal cytoskeletal and adhesion markers (EPCAM, KRT8, KRT18, KRT19) with canonical progenitor and secretory effectors (KIT, ALDH1A3, SLPI, LTF, GABRP). This co-expression profile definitively classifies this cluster as Luminal Progenitor Cells/Secretory luminal cells within the mammary epithelium. Unified nomenclature: luminal adaptive secretory precursor (LASP)

Inherited from Type

Set of Labels Description

Cell type annotation based on clustering and marker analysis.

Annotation Method

manual