Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Fibroblast

Ontology Term: fibroblast of breastCL:4006000
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: breast fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL1A1, DCN, FN1, IGFBP6, MMP2, PDGFRA, PDPN
Canonical Marker Genes: COL1A1, FN1, DCN, PDGFRA, MMP2, PDPN
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: This cluster is characterized by high expression of structural extracellular matrix genes (COL1A1, FN1, DCN), collagen-remodeling factors (MMP2), and key fibroblast lineage markers (PDGFRA, PDPN). This distinct expression profile classifies this cell cluster as Mammary Stromal Fibroblasts.

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual