Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Vascular_Endothelial

Ontology Term: microvascular endothelial cellCL:2000008
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: endothelial cell, vascular endothelial cell
Category Class of which the cell type is a subclass.: blood vessel endothelial cellCL:0000071
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: The endothelial cell ontology is not entirely clear.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ESAM, ANGPT2, CDH5, CLDN5, ECSCR, FABP4, ENG, PLVAP
Canonical Marker Genes: CDH5, CLDN5, ESAM, ENG, ANGPT2, ECSCR, PLVAP, FABP4
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: This cell cluster expresses definitive vascular endothelial junctional molecules (CDH5, CLDN5, ESAM), endothelial signaling factors (ENG, ANGPT2, ECSCR), and microvascular transport markers (PLVAP, FABP4). This distinct signature confirms the population as Vascular Endothelial Cells.

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual