Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Macrophage

Ontology Term: macrophageCL:0000235
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: histiocyte, myeloid cell
Category Class of which the cell type is a subclass.: myeloid leukocyteCL:0000766
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL3, CCL4, CD163, FCER1G, IDO1, IL1B
Canonical Marker Genes: CCL3, CCL4, CD163, FCER1G, IDO1, IL1B
Rationale: This cluster exhibits co-expression of classic myeloid lineage and scavenger receptor genes (CD163, FCER1G), chemokine effectors (CCL3, CCL4), pro-inflammatory signaling (IL1B), and immunomodulatory enzymes (IDO1). This signature annotates the cluster as Macrophages / Myeloid Cells within the mammary tissue stroma.

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual