Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Lymphatic_Endothelial

Ontology Term: endothelial cell of lymphatic vesselCL:0002138
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LEC, lymphatic endothelial cell
Category Class of which the cell type is a subclass.: endothelial cell of vascular treeCL:0002139
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDPN, ESAM, ANGPT2, CDH5, CLDN5, ECSCR, FABP4
Canonical Marker Genes: PDPN, CDH5, CLDN5, ESAM, ENG, ANGPT2, ECSCR, FABP4
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Co-expression of the canonical lymphatic marker PDPN alongside pan-endothelial junctional and signaling genes (CDH5, CLDN5, ESAM, ENG, ANGPT2, ECSCR, FABP4) identifies this cluster as Lymphatic Endothelial Cells (LECs) within the mammary microenvironment.

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual