Human kidney cell atlas

The Human Cell Atlas Kidney (HCKA) v1 is a comprehensive single-cell reference of the human kidney, integrating ~1 million cells from 18 datasets with healthy tissue and multiple disease states, including AKI, glomerulonephritis, transplant rejection, polycystic kidney disease, and diabetic kidney disease. Using a harmonized analysis framework, the atlas defines 123 kidney cell populations. This resource provides a high-resolution map of kidney cellular diversity and disease mechanisms, serving as a reference for the study of kidney function and pathology. The atlas includes both single-cell and single-nucleus datasets, which are harmonized at the cell type annotation level to align identities across modalities while preserving modality-specific data structures, enabling unbiased cross-platform comparisons.