Healthy intestinal mucosa: a control reference for inflammatory bowel disease

Colonocyte CEACAM-

Ontology Term: early colonocyteCL:4047018
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: early enterocyte of colon
Category Class of which the cell type is a subclass.: colonocyteCL:1000347
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FABP1, CA1, CA2, CA12, ANPEP
Canonical Marker Genes: CA1, CA2, CEACAM5, CEACAM7, ANPEP
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: This colonocyte subtype is the intermediate colonocyte that lack progenitor cell markers like OLFM4, yet the polarization marker ANPEP and maturation markers like AQP8 and CEACAM5/7 are expressed at lower levels compare to matured colonocyte.
Rationale DOI: https://doi.org/10.1038/nri3608

Set of Labels Description: The annotation is a result of manual and algorithmic annotation using multiple public reference datasets.
Annotation Method: both
Algorithm Name: scVI/scANVI
Algorithm Version: 1.0.1
Algorithm URL: https://github.com/scverse/scvi-tools
Annotation Transfer Reference: https://www.gutcellatlas.org
Annotation Transfer Description: We transfer the annotations from the public reference to our data set, then assess the cluster transcriptomic similarity, transferred label homogeneity and canonical marker expressions for final annotations.