memory_B_unknown

Ontology Term

memory B cellCL:0000787

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

memory B-lymphocyte, memory B-cell, memory B lymphocyte

Category

Class of which the cell type is a subclass.

B cellCL:0000236

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

MS4A1, CD79A, CD27, TNFRSF13B

Canonical Marker Genes

unknown

Rationale

B cells were identified via RCAv2. Integration and sub-clustering of all B cells were performed, and clusters were annotated based on marker genes. These memory B cell clusters could not be clearly classified by their IGHM expression levels as memory_B_IGHMhi or memory_B_IGHMlo.

Inherited from author_cell_type

Set of Labels Description

These author cell type labels were assigned largely at the per-cluster level. We identified broad cell types using RCAv2-based clustering (B, CD34+ haematopoietic stem and progenitor cell (HSPC), myeloid, natural killer (NK), plasma cell, plasmacytoid dendritic cell (pDC), platelet, and T). We then performed cell population-specific (B; myeloid + pDC; CD4+ T and dnT; non-CD4+ T and NK and ILC) integration (Seurat RPCA) and sub-clustering (Louvain clustering), and annotated clusters based on their marker genes.

Annotation Method

manual