Terms that have the same, or nearly the same, meaning as the selected cell type.
ACs, AC, amacrine neuron
Category
Class of which the cell type is a subclass.
GABAergic Glycinergic amacrine cells
Ontology Assessment
Disagreements with any aspect of the Cell Ontology.
The Cell Ontology has two existing terms for two amacrine subclasses: GABAergic amacrine cells (CL:4030027) and Glycinergic amacrine cells (CL:4030028). They have specific markers: GABA-synthetic enzymes GAD1 and GAD2 for GABAergic amacrine cells; glycine transporter SLC6A9 for Glycinergic amacrine cells. However, the Cell Ontology does not have a term for amacrine cells expressing markers for both of these amacrine subclasses.
The evidence for the new term is that around 10 amacrine clusters in the Human Retina Cell Atlas highly express markers for both GABAergic and Glycinergic amacrine cells as discussed in the following publications:
https://doi.org/10.1038/s41598-020-66092-9
https://doi.org/10.1523/JNEUROSCI.0471-20.2020
The new ontology term of GABAergic Glycinergic amacrine cells should be at the same level as GABAergic amacrine cells (CL:4030027) and Glycinergic amacrine cells (CL:4030028). Its parent term should be CL:0000561, and there is no synonym term for this new term.
Marker Gene Evidence
Gene markers used by researcher to assign this cell annotation.
58.3%Unassigned+24.5%Gly6+16.5%Gly1 of the Sanes dataset; 62.9%Unassigned+35.7%Gl4 of the macaque dataset; 93.2%AC34 of the mouse dataset; Known markers are curated from human, macaque, and mouse markers.
Inherited from author_cell_type
Set of Labels Description
Over 89 amacrine cell types were identified among over 571K amacrine nuclei in the current atlas. These 89 cell types can be categorized into GABAergic amacrine cells, Glycinergic amacrine cells, and Both type using marker genes, specifically the GABA-synthetic enzymes GAD1 and GAD2, and the glycine transporter SLC6A9. Based on previously characterized markers, 14 of the 89 amacrine cell clusters could be annotated as known amacrine types.
