Single cell atlas of the human trabecular meshwork and ciliary body - snRNA-seq

Main

Cell Metadata

Ciliary_Muscle

Ontology Term: ciliary muscle cellCL:1000443
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: smooth muscle cell of ciliary body
CategoryClass of which the cell type is a subclass.: smooth muscle cellCL:0000192
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: CHRM3, TPM2
Canonical Marker Genes: CHRM3
Rationale: This ciliary muscle major class is annotated by the marker CHRM3.

Set of Labels Description: This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-nucleus RNA-seq, we analyzed over 1 million cells from 70 healthy donors, identifying 9 major cell classes and 18 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.
Annotation Method: manual

Ontology Term: ciliary muscle cellCL:1000443
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: smooth muscle cell of ciliary body
CategoryClass of which the cell type is a subclass.: smooth muscle cellCL:0000192
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: CHRM3, TPM2
Canonical Marker Genes: CHRM3
Rationale: This ciliary muscle major class is annotated by the marker CHRM3.

Set of Labels Description: This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-nucleus RNA-seq, we analyzed over 1 million cells from 70 healthy donors, identifying 9 major cell classes and 18 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.
Annotation Method: manual