Single cell atlas of the human trabecular meshwork and ciliary body - scRNA-seq

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Cell Metadata

CB_NPCE_1

Ontology Term: non-pigmented ciliary epithelial cellCL:0002304
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: NPE cell
CategoryClass of which the cell type is a subclass.: neurecto-epithelial cellCL:0000710
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: CLU, SOD1, FTH1, RPL41, PTGDS
Canonical Marker Genes: LRP2, COL9A1, OPTC
Rationale: This non-pigmented ciliary epithelial sub-class is annotated by the marker LRP2, COL9A1 and OPTC, but distinct from CB_NPCE_2 claster with different express genes

Set of Labels Description: This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-cell RNA-seq, we analyzed over 332K cells from 36 healthy donors, identifying 9 major cell classes and 19 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.
Annotation Method: manual

Ontology Term: non-pigmented ciliary epithelial cellCL:0002304
SynonymsTerms that have the same, or nearly the same, meaning as the selected cell type.: NPE cell
CategoryClass of which the cell type is a subclass.: neurecto-epithelial cellCL:0000710
Marker Gene EvidenceGene markers used by researcher to assign this cell annotation.: CLU, SOD1, FTH1, RPL41, PTGDS
Canonical Marker Genes: LRP2, COL9A1, OPTC
Rationale: This non-pigmented ciliary epithelial sub-class is annotated by the marker LRP2, COL9A1 and OPTC, but distinct from CB_NPCE_2 claster with different express genes

Set of Labels Description: This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-cell RNA-seq, we analyzed over 332K cells from 36 healthy donors, identifying 9 major cell classes and 19 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.
Annotation Method: manual